Meet The Greatest Ibogaine Psychedelic Scientist You’ve Never Heard Of

About the conversation

🧠 THANK YOU FOR BEING A PART OF THE GIANT'S SHOULDER FAMILY Here is the full, ad free version of my conversation with Dalibor Sames. Dalibor Sames is the chemist who reverse-engineered ibogaine into a version that appears to erase heroin addiction in a single dose, without the cardiac risk that can kill people on the original drug. He runs his lab at Columbia University, where he has spent two decades taking psychoactive molecules apart atom by atom. He also took his own medicine, and says he watched the molecule's exact 3D structure rotate in front of him for thirty-six hours straight. Expect to learn: - Matrix pharmacology: why one drug hitting one target cannot explain what ibogaine does - One atom: how a single edit deletes ibogaine's fatal cardiac risk - The secret opioid: why a common antidepressant turned out to be one for thirty years - Thirty-six hours: what he saw during a flood dose of his own molecule - Overnight: why interest in alcohol seems to vanish after a single session GS EPISODES MENTIONED Andrew Gallimore - No.1 DMT Neurobiologist: Alien Worlds, DMT Entity Encounters, Attractor States and Consciousness: https://youtu.be/USgWrxEFWDA David Luke - Meet the Professor of Paranormal Consciousness - DMT Entities, Telepathy Tapes & OBE's: https://youtu.be/qLKD1gt1X5o GUEST LINKS Columbia Chemistry Faculty Page: https://www.chem.columbia.edu/content/dalibor-sames Sames Lab: https://www.samesgroup.org/professor-dalibor-sames Gilgamesh Pharmaceuticals: https://www.gilgameshpharmaceutical.com/ Oxa-Iboga paper (Nature Communications, 2024): https://doi.org/10.1038/s41467-024-51856-y Beond Ibogaine Clinic: https://beondibogaine.com LISTEN ON Spotify - https://open.spotify.com/show/5m3Gta5MtIYdk59pb2GJ7M Apple - https://podcasts.apple.com/ie/podcast/the-giants-shoulder/id1752486249 SKOOL Want a full breakdown of your own conscious inner experience? Join the Giant's Shoulder community: https://www.skool.com/the-giants-shoulder-6526/about FOLLOW EVAN https://x.com/evan_mcgl TIMESTAMPS 0:00:00 Trailer 0:02:39 Meet the Chemist Who Fell for a Molecule's Shape 0:04:13 The Dogma That the Adult Brain Can't Heal 0:09:00 Why Synapses Might Explain Every Brain Disorder 0:10:28 Reverse-Engineering Nature's Own Drugs 0:13:57 The Paper That Changed Everything About Addiction 0:17:14 Why Ibogaine Breaks Every Rule of Pharmacology 0:30:21 The Weakest Drug That Works the Strongest 0:35:34 The Traffic Jam That Explains Matrix Pharmacology 0:39:47 A Human Genome Project — For One Molecule 0:43:17 Deciding to Take Ibogaine Himself 0:45:31 Inside a 36-Hour Flood Dose 0:50:07 The Chapter Called "Treatment" 0:51:55 Ibogaine Shows Him the Future of Design 0:55:30 Seeing Ibogaine's 3D Molecular Structure 0:58:43 High-Fiving a Molecule 1:02:16 "This Is a Computational Technology" 1:12:05 The Simulation So Real It Panicked Him 1:19:55 Did He Earn This Experience? 1:26:25 Six Months Later — What Actually Changed 1:31:30 Did This Change His View of Consciousness? .....Email for sponsorship enquiries: evan@thegiantsshoulder.com