Episode

Meet The Neuroscientist Decoding Your Bodies Cannabis System

Apr 18, 20261h 4m 8.6K views

About the conversation

Get A Full Breakdown Of Your Own Conscious Inner Experience (100% Free): https://www.skool.com/the-giants-shoulder-6526/about Dr. Matt Hill is one of the world’s leading cannabis neuroscientists, former president of the International Cannabinoid Research Society, and a researcher with over 21,000 citations studying how the endocannabinoid system regulates the brain and body. Cannabis affects different people in completely opposite ways — calming one person while causing crippling anxiety in another — and Hill explains why the biology makes this inevitable, why both sides of the cannabis debate are getting it wrong, and why legalisation in Canada accidentally destroyed the very research that could have answered our biggest questions. Expect to learn why CB1 is the most widely distributed receptor in the brain yet almost nobody has heard of it, how endocannabinoids work backwards across the synapse unlike any other signalling system, why low-dose THC calms the amygdala but high-dose THC causes paranoia and anxiety, why women get higher than men on the same dose of cannabis due to a liver enzyme difference, why only a third of people genuinely benefit from medical cannabis while a third get nothing, how cannabis triggers schizophrenia in genetically vulnerable people without actually causing the disease, why Canadian legalisation killed cannabis clinical trials through a bureaucratic GMP-versus-GPP standoff, what the real cardiovascular risks of chronic cannabis use are, why cannabis users paradoxically have lower obesity rates, and much more… Timestamps: 00:00 Trailer 02:00 Dr. Matt Hill — Cannabis Neuroscientist 02:25 The Endocannabinoid System: Your Body’s Own Cannabis 04:23 Every Biological Function It Controls 06:30 The Most Distributed Receptor Nobody’s Heard Of 07:20 Why Cannabis Science Is So Politically Toxic 09:35 Both Sides Are Wrong: The Three Blind Men Problem 10:23 The Frustrating Polarity of the Cannabis Debate 12:37 Your Personal Experience Doesn’t Generalise 16:25 Why Cannabis Feels Like a Different Drug for Different People 17:52 Retrograde Signalling: How Cannabis Works Backwards 20:08 Low Dose Calms, High Dose Causes Paranoia — Here’s Why 22:24 Women Produce More 11-Hydroxy-THC Than Men 25:52 Why Receptor Distribution Makes Cannabis Unpredictable 27:11 The PET Scan Problem: Why We Can’t Map Your Receptors 29:04 Why Cannabis Companies Don’t Fund Real Research 31:25 How Legalisation Accidentally Killed Cannabis Science 34:46 The GMP vs GPP Bureaucratic Disaster 38:09 David Nutt: Drug Policy Driven by Politics Not Science 43:01 Why You Can’t Standardise Cannabis Dosing Like Alcohol 49:44 The Three Thirds Rule: Benefit, Side Effects, or Nothing 53:05 The Best Evidence: Where Cannabis Actually Works 53:36 Schizophrenia Risk — It’s a Trigger, Not a Cause 55:52 Cardiovascular Risk: The Under-Discussed Real Danger 57:02 Does Exercise Cancel Out Cannabis Heart Risk? 58:14 The Obesity Paradox: Why Cannabis Users Are Thinner 01:01:03 Chronic Pain, MS, Epilepsy and PTSD — The Medical Evidence 01:03:18 Final Thoughts and a Plea for Billionaire Stoners ... Email for sponsorship enquiries: evan@thegiantsshoulder.com ❤️ Subscribe to our main channel - https://www.youtube.com/@thegiantsshoulder?sub_confirmation=1 💚 Follow on Spotify - https://open.spotify.com/show/5m3Gta5MtIYdk59pb2GJ7M?si=Ka2rAQv7TyqiC9wvGwERpA 💜 Follow on Apple Podcasts - https://podcasts.apple.com/ie/podcast/the-giants-shoulder/id1752486249 Download my FREE EBook 26 Neuroscience Books for 2026 HERE: https://thegiantsshoulder.com/

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